Faculty
RESEARCH INTERESTS
Biosensing and molecular diagnostics;
Development of novel strategies to combat antimicrobial resistance.
EDUCATION
Ph.D. (Cell Biology), University of Science and Technology of China, 2003-2009
B. S. (Life Sciences), Hubei Normal University, 1999-2003
RESEARCH AND PROFESSIONAL EXPERIENCE
Research Associate Professor, Southern University of Science and Technology, 2018-present;
Assistant Professor/Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 2009-2018
Visiting Scholar, the University of Hong Kong, 2017- 2018
Visiting Scholar, Morehouse School of Medicine, 2006- 2007
GRANTS
Single-molecule detection and imaging of ubiquitin-like modifications with genetically-encoded protein tag-based biosensors; National Natural Science Foundation of China, Principal Investigator, 2017-2020.
Molecular delineation of Mis12 complex assembly dynamics during chromosome segregation; National Natural Science Foundation of China, Principal Investigator, 2011-2013.
Quantum dots-based labeling technique to monitor viral invasion and host response; National Basic Research Program of China (973 Program), 2011-2015.
HONORS AND AWARDS
Shenzhen Overseas Talents-C (2018), Human Resources and Social Security Administration of Shenzhen Municipality
Outstanding Young Scholar in Talents Project(2017)，GuangDong TeZhi Program, Guangdong Province
Guangdong Natural Science Award(Second class, 2017), Government of Guangdong Province
Member of the Youth Innovation Promotion Association(2015), Chinese Academy of Sciences
High-Level Professional in Shenzhen(2014), Human Resources and Social Security Administration of Shenzhen Municipality
Shenzhen Natural Science Award(Second class, 2014), Science and Technology Innovation Commission of Shenzhen Municipality
SELECTED PUBLICATIONS
[1] Li Y.Y., Yang Y.,* Zhang C.Y.* Visualization and Quantification of Sortase Activity at the Single-Molecule Level via Transpeptidation-Directed Intramolecular F?rster Resonance Energy Transfer. Anal. Chem., 2018, 90, 13007-13012. (Nature Index article, IF=6.042)
[2] Xu A. J., Yang Y.,* Zhang C.Y.* Transpeptidation-directed intramolecular bipartite tetracysteine
display for sortase activity assay. Chem. Commun., 2018, 54, 8116-8119. (Nature Index article, IF=6.29)
[3] Yang Y., Liang Y., Zhang C.Y.* Label-Free and Homogenous Detection of Caspase-3-Like Proteases by Disrupting Homodimerization-Directed Bipartite Tetracysteine Display. Anal. Chem., 2017, 89, 4055-4061. (Nature Index article, IF=6.042)
[4] Zhou J., Yang Y., Zhang C.Y.* Toward Biocompatible Semiconductor Quantum Dots: From Biosynthesis and Bioconjugation to Biomedical Application. Chem. Rev., 2015, 115, 11669-11717. (SCI, IF=52.613).
[5] Wang L. J.,? Yang Y.,? Zhang C.Y.* Phosphorylation-directed assembly of a single quantum dot based nanosensor for protein kinase assay. Anal. Chem., 2015, 87, 4696-4703. (Nature Index article, IF=6.042)
[6] Yang Y., Zhang C.Y.* Visualizing and Quantifying Protein PolySUMOylation at the Single-Molecule Level. Anal. Chem., 2014, 86, 967-972. (Nature Index article, Editors’ Highlight)
[7] Ma F.,? Yang Y.,? Zhang C.Y.* Ultrasensitive Detection of Transcription Factors Using Transcription-Mediated Isothermally Exponential Amplification-Induced Chemiluminescence. Anal. Chem., 2014, 86, 6006-6011. (Nature Index article, IF=6.042)
[8] Yang Y., Zhang C.Y.* Simultaneous measurement of SUMOylation using SNAP/CLIP-tag-mediated translation at the single-molecule level. Angew. Chem. Int. Ed., 2013, 52, 691-694. (Nature Index article, IF=12.102)
[9] Zhou J.,? Yang Y.,? Zhang C.Y.* A low-temperature solid-phase method to synthesize highly
fluorescent carbon nitride dots with tunable emission. Chem. Commun., 2013, 49, 8605-8607. (Nature Index article, Back cover)
[10] Yang Y., Zhang C.Y.* Sensitive Detection of Intracellular Sumoylation via SNAP Tag-Mediated
Translation and RNA Polymerase-Based Amplification. Anal. Chem., 2012, 84, 1229-1234. (Nature
Index article, IF=6.042)
[11] Yang Y., Wu F., Ward T., Yan F., Wu Q., Wang Z.Y., McGlothen T., Peng W., You T. P., Sun M. K., Cui T. X., Hu R. M., Dou Z., Zhu J. D., Xie W., Rao Z. H., Yao X. B.* Phosphorylation of HsMis13 by aurora B is essential for assembly of functional kinetochore. J. Biol. Chem., 2008, 283, 26726-26736.