師資
個(gè)人簡(jiǎn)介：
2009 年畢業(yè)于北京大學(xué)醫(yī)學(xué)部醫(yī)學(xué)實(shí)驗(yàn)專業(yè)，取得學(xué)士學(xué)位，2012年在英國(guó)曼徹斯特大學(xué)生命科學(xué)系取得博士學(xué)位。博士期間以研究蛋白-DNA 結(jié)合特異性以及細(xì)胞周期 G2/M 期的調(diào)控為主題，發(fā)現(xiàn)并且闡明了一個(gè)促癌轉(zhuǎn)錄因子FOXM1調(diào)控G2/M期的特殊機(jī)制。在完成博士研究之后，于2013年來(lái)到歐洲生物信息研究所(European Bioinformatics Institute)從事博士后工作，進(jìn)行表觀遺傳學(xué)、生物信息學(xué)，以及單細(xì)胞測(cè)序方面的研究。2016年加入維康桑格研究所(Wellcome Sanger Institute)成為高級(jí)研究員。2019年加入南方科技大學(xué)生物系，任助理教授。
研究領(lǐng)域：
(1) 單細(xì)胞表觀遺傳以及轉(zhuǎn)錄組測(cè)序技術(shù)開(kāi)發(fā)
(2) 基因組學(xué)數(shù)據(jù)的挖掘以及生物信息分析
(3) 以T細(xì)胞和干細(xì)胞為模型，研究轉(zhuǎn)錄因子以及染色質(zhì)復(fù)合物在控制細(xì)胞命運(yùn)決定以及記憶中的作用和機(jī)制
工作經(jīng)歷：
2019 至 今 南方科技大學(xué)生物系 助理教授
2016 至 2019 維康桑格研究所 高級(jí)研究員
2013 至 2016 歐洲生物信息研究所 博士后
2012 至 2013 曼徹斯特大學(xué)生命科學(xué)系 研究助理
學(xué)習(xí)經(jīng)歷：
2009 至 2012 曼徹斯特大學(xué)生命科學(xué)系 博士
2005 至 2009 北京大學(xué)醫(yī)學(xué)部醫(yī)學(xué)實(shí)驗(yàn)專業(yè) 本科
代表文章： (*共同一作)
學(xué)術(shù)文章：
1. Henriksson, J.*, Chen, X.*, Gomes, T., Ullah, U., and Meyer, K.B. (2019). Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation. Cell 176, 1–15.
2.Zhang, W.*, Chronis, C.*, Chen, X.*, Zhang, H., Spalinskas, R., Pardo, M., Chen, L., Wu, G., Zhu, Z., Yu, Y., et al. (2019). The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell 24, 138–152.e8.
3.Chen, X., Miragaia, R.J., Natarajan, K.N., and Teichmann, S.A. (2018). A rapid and robust method for single cell chromatin accessibility profiling. Nat. Commun. 9, 5345.
4.Jia, G.*, Preussner, J.*, Chen, X.*, Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al. (2018). Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat. Commun. 9, 4877.
5.Hagai, T., Chen, X., Miragaia, R.J., Rostom, R., Gomes, T., Kunowska, N., Henriksson, J., Park, J.-E., Proserpio, V., Donati, G., et al. (2018). Gene expression variability across cells and species shapes innate immunity. Nature 563, 197–202.
6.Pramanik, J., Chen, X., Kar, G., Henriksson, J., Gomes, T., Park, J.-E., Natarajan, K., Meyer, K.B., Miao, Z., McKenzie, A.N.J., et al. (2018). Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 10, 76.
7.Chen, X., Ji, Z., Webber, A., and Sharrocks, A.D. (2016). Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res. 44, 1566–1578.
8.Yu, Y., Tsang, J.C.H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L.S., Lu, L., et al. (2016). Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 539, 102–106.
9.Aguilar-Martinez, E., Chen, X., Webber, A., Paul Mould, A., Seifert, A., Hay, R.T., and Sharrocks, A.D. (2015). Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin. Proc. Natl. Acad. Sci. U. S. A. 112, E4854–E4863.
10.Wiseman, E.F., Chen, X., Han, N., Webber, A., Ji, Z., Sharrocks, A.D., and Ang, Y.S. (2015). Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma. Mol. Cancer 14, 69.
11.Chen, X., Müller, G.A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A.D., and Engeland, K. (2013). The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol. Cell. Biol. 33, 227–236.
評(píng)論與綜述：
1.Chen, X., Teichmann, S.A., and Meyer, K.B. (2018). From Tissues to Cell Types and Back: Single-Cell Gene Expression Analysis of Tissue Architecture. Annu. Rev. Biomed. Data Sci. 1, 29-51.
2.Chen, X., Love, J.C., Navin, N.E., Pachter, L., Stubbington, M.J.T., Svensson, V., Sweedler, J.V., and Teichmann, S.A. (2016). Single-cell analysis at the threshold. Nat. Biotechnol. 34, 1111–1118.
3.Vieira Braga, F.A.*, Teichmann, S.A., and Chen, X.* (2016). Genetics and immunity in the era of single-cell genomics. Hum. Mol. Genet. 25, R141–R148.
圖書章節(jié)：
1.Kunowska, N.*, Chen, X*. (2019). ChIPmentation for Low-Input Profiling of In Vivo Protein-DNA Interactions. Methods Mol Biol. 1979: 269-282.