師資
田瑞軍博士，國家杰出青年基金獲得者，南方科技大學(xué)理學(xué)院化學(xué)系終身教授、南方科技大學(xué)技術(shù)轉(zhuǎn)移中心主任、南方科技大學(xué)光明高等研究院副院長、化學(xué)生物學(xué)與組學(xué)分析研究中心主任，中國蛋白質(zhì)組組織CNHUPO副理事長、中國化學(xué)會(huì)色譜專業(yè)委員會(huì)副理事長、全國色譜會(huì)學(xué)術(shù)委員會(huì)常務(wù)委員、中國質(zhì)譜學(xué)會(huì)理事和中國分子系統(tǒng)生物學(xué)學(xué)會(huì)理事。2008年于中國科學(xué)院大連化學(xué)物理研究所獲得分析化學(xué)博士學(xué)位，師從鄒漢法研究員，并獲得中國科學(xué)院院長優(yōu)秀獎(jiǎng)和中國科學(xué)院優(yōu)秀畢業(yè)生獎(jiǎng)勵(lì)。同年加入加拿大渥太華系統(tǒng)生物學(xué)研究所進(jìn)行博士后研究，師從Daniel Figeys教授。2010年加入加拿大多倫多大學(xué)和西奈山醫(yī)院繼續(xù)博士后研究，師從Tony Pawson院士，并獲得加拿大國立衛(wèi)生研究院（CIHR）博士后基金資助。2014年起受聘南方科技大學(xué)化學(xué)系副教授（研究員），并于2020年晉升終身正教授。致力于蛋白質(zhì)組學(xué)方法學(xué)研究，并在蛋白質(zhì)復(fù)合物、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)和腫瘤微環(huán)境等生物醫(yī)學(xué)方向開展應(yīng)用研究。已在國際主流學(xué)術(shù)期刊Nature、Nat. Chem. Biol.、Cell Chem. Biol.、Nat. Commun.、PNAS、Mol. Cell. Proteomics、Anal. Chem.等上發(fā)表論文百余篇。作為負(fù)責(zé)人獲國家自然科學(xué)基金重大研究計(jì)劃集成項(xiàng)目、科技部國家重點(diǎn)研發(fā)計(jì)劃子課題等資助。作為客座主編在Curr. Opin. Chem. Biol.等發(fā)表?？瘍刹俊?dān)任分析化學(xué)和色譜雜志編委。
榮譽(yù)獎(jiǎng)勵(lì)：
2021年 國家自然科學(xué)基金委杰出青年基金
2019年 廣東省自然科學(xué)基金委杰出青年基金
2019年 深圳市鵬城學(xué)者特聘教授
2014年 深圳市孔雀計(jì)劃B類
2012年 2012 Young Investigator Award, 國際蛋白質(zhì)結(jié)構(gòu)分析和蛋白質(zhì)組學(xué)協(xié)會(huì)(IAPSAP)
代表性論文：
Invited reviews:
1. P. W. Huang,? W. N. Gao,? C. Y. Fu,? R. J. Tian,* Functional and clinical proteomic exploration of pancreatic cancer, Mol. Cell. Proteomics, 2023,22(7):100575. (Invited Reviews)
2. Z. Y. Liu,? X. Chen,? S. R. Yang, R. J. Tian,* F. J. Wang,* Integrated mass spectrometry strategy for functional protein complex discovery and structural characterization, Curr. Opin. Chem. Biol., 2023,74:102305. (Invited Reviews)
3. Y. H. Mao, X. Wang, P. W. Huang, R. J. Tian,* Spatial proteomics for understanding the tissue microenvironment, Analyst, 2021, 146, 3777-3798. (Invited Reviews)
4. J. N. Zheng,? X. Chen,? Y. Yang, C. S. H. Tan, R. J. Tian,* Mass spectrometry-based protein complex profiling in time and space, Anal. Chem., 2021, 93, 598–619. (Invited Reviews)
5. X. T. Ye,? J. Tang,? Y. H. Mao,? X. Lu, Y. Yang, W. D. Chen, X. Y. Zhang, R. L. Xu, R. J. Tian,* Integrated proteomics sample preparation and fractionation: method development and applications, TrAC Trends Anal. Chem., 2019, 120, 115667. (Highlighted as Front Cover)
6. R. J. Tian,* Exploring intercellular signaling by proteomic approaches, Proteomics, 2014, 14(4-5):498-512. (Invited Reviews)
Research articles:
1. Y. H. Mao,? Y. Chen,? Y. Li,? L. D. Ma,? X. Wang, Q. Wang, A. He, X. Liu, T. Y. Dong, W. N. Gao, Y. F. Xu, L. Liu, L. Ren, Q. Liu, P. Zhou, B. Hu, Y. W. Zhou,* R. J. Tian,* Z. L. Shi,* Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury, Cell Reports, 2024, 43, 2,113689.
2. Q. Wu,? J. N. Zheng,? X. T. Sui,? C. Y. Fu,? X. Z. Cui, B. Liao, H. C. Ji, Y. Luo, A. He, X. Lu, C. S. H. Tan,* R. J. Tian,* High-throughput drug target discovery by fully automated proteomics sample preparation platform, Chemical Science, 2024, 15(8):2833-2847.
3.Y. C. Weng,? W. D. Chen,? Q. Kong,? R. X. Wang, R. X. Zeng, A. He, Y. J. Liu, Y. H. Mao, Y. Q. Qin, W. S. C. Ngai, H. Zhang, M. Ke, J. Wnag, R. J. Tian,* P. R. Chen,* DeKinomics pulse-chases kinase functions in living cells, Nat. Chem. Biol., 2024, 20(5):615-623.
4. J. N. Zheng,?* Z. D. Zheng,? C. Y. Fu,? Y. C. Weng, A. He, X. T. Ye, W. N. Gao, R. J. Tian,* Deciphering intercellular signaling complexes by interaction-guided chemical proteomics, Nat. Commun., 2023, 14, 4138.
5. X. Chen,? S. P. Ji,? Z. Y. Liu, X. Yuan, C. S. Xu, R. X. Qi, A. He, H. Zhao, H. P. Song, C. L. Xiao, W. N. Gao, P. Chen, R. Luo, P. F. Li,* F. J. Wang,* X. M. Yang, R. J. Tian,* Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics, Cell Chem. Biol., 2022, 29, 1024-1036.
6. M. Ke,? X. Yuan,? A. He, P.Y. Yu, W.D. Chen, Y. Shi, T. Hunter, P. Zou, R. J. Tian,* Spatiotemporal Profiling of Cytosolic Signaling Complexes in Living Cells by Selective Proximity Proteomics, Nat. Commun., 2021, 12, 71.
7. Y. Shi,* W. N. Gao, N. K. Lytle, P. W. Huang, X. Yuan, A. M. Dann, M. Ridinger, K. E. DelGiorno, G. Erikson, H. Y. Sun, J. Meisenhelder, E. Terenziani, P. Santisakultarm, U. Manor, R. L. Xu, M. Leblanc, S. E. Umetsu, E. A. Collisson, A. M. Lowy, T. Reya, T. R. Donahue, M. Downes, G. M. Wahl, R. M. Evans, T. Pawson, R. J. Tian,* T. Hunter,* Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring, Nature, 2019, 569, 131-135.
8. B. Z. Chu,? A. He,? Y. T. Tian, W. He, P. Z. Chen, J. T. Hu, R. L. Xu, W. B. Zhou, M. J. Zhang, P. Y. Yang, S. S. C. Li, Y. Sun,* P. F. Li,* T. Hunter, R. J. Tian,* Photoaffinity-engineered protein scaffold for systematically exploring Native phosphotyrosine signaling complexes in tumor samples. Proc. Natl. Acad. Sci. U. S. A., 2018, 115, E8863-E8872.
9. R. J. Tian,*? H. P. Wang,? G. D. Gish, E. Petsalaki, A. Pasculescu, Y. Shi, M. Mollenauer, R. D. Bagshaw, N. Yosef, T. Hunter, A. Gingras, A. Weiss,* T. Pawson, A combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor, Proc. Natl. Acad. Sci. U. S. A. , 2015, 112, E1594–E1603.
10. Q. Kong,? M. Ke,? Y. C. Weng, Y. Q. Qin, A. He, P. F. Li,* Z. W. Cai,* R. J. Tian,* Dynamic phosphotyrosine-dependent signaling profiling in living cells by two-dimensional proximity proteomics, J. Proteome Res., 2022, 21, 2727–2735.
11. Q. Kong,? Y. C. Weng,? Z. D. Zheng, W. D. Chen, P. F. Li,* Z. W. Cai,* R. J. Tian,* Integrated and high-throughput approach for sensitive analysis of tyrosine phosphoproteome, Anal. Chem., 2022, 94, 40, 13728–13736.
12. Y. H. Mao,? P. Z. Chen,? M. Ke, X. Chen, S. P. Ji, W. D. Chen, R. J. Tian,* Fully integrated and multiplexed sample preparation technology for sensitive interactome profiling, Anal. Chem., 2021, 93, 5, 3026–3034.
13. P. W. Huang, Q. Kong, W. N. Gao, B. Z. Chu, H. Li, Y. H. Mao, Z. W. Cai, R. L. Xu, R. J. Tian,* Spatial proteome profiling by immunohistochemistry-based laser capture microdissection and data-independent acquisition proteomics, Anal. Chim. Acta, 2020, 1127, 140-148.
14. Q. Kong,? P. W. Huang,? B. Z. Chu, M. Ke, W. D. Chen, Z. D. Zheng, S. P. Ji, Z. W. Cai, P. F. Li, and R. J. Tian,* High-throughput and integrated chemical proteomic approach for profiling phosphotyrosine signaling complexes, Anal. Chem., 2020, 92, 8933-8942.
15. X. Lu,? Z. K. Wang,? Y. Gao, W. D. Chen, L. J. Wang, P. W. Huang, W. N. Gao, M. Ke, A. He, and R. J. Tian,* Autoproteome chip system for fully automated and integrated proteomics sample preparation and peptide fractionation, Anal. Chem., 2020, 92, 8893-8900.
16. P. W. Huang, H. J. Li, W. N. Gao, Z. W. Cai,* R. J. Tian,* A fully integrated spintip-based approach for sensitive and quantitative profiling of region-resolved in vivo brain glycoproteome, Anal. Chem., 2019, 91, 9181-9189.
17. R. L. Xu,? J. Tang,? Q. T. Deng, W. He, X. J. Sun, L. Xia, Z. Q. Cheng, L. S. He, S. Y. You, J. T. Hu, Y. X. Fu, J. Zhu, Y. X. Chen, W. N. Gao, A. He, Z. Y. Guo, L. Lin, H. Li, C. F. Hu, R. J. Tian,* Spatial-resolution cell type proteome profiling of cancer tissue by fully integrated proteomics technology, Anal. Chem., 2018, 90, 5879?5886.
18. W. D. Chen, S. Wang, S. Adhikari, Z. H. Deng, L. J. Wang, L. Chen, M. Ke, P. Y. Yang, R. J. Tian,* Simple and integrated spintip-based technology applied for deep proteome profiling, Anal. Chem., 2016, 88, 4864-4871.