師資
個(gè)人簡(jiǎn)介：
牛鋒鋒博士，現(xiàn)為南方科技大學(xué)生命科學(xué)學(xué)院研究副教授，碩士生導(dǎo)師。本科畢業(yè)于南開(kāi)大學(xué)，隨后在中科院生物物理研究所獲得生物化學(xué)與分子生物學(xué)專(zhuān)業(yè)博士學(xué)位。2016年加入南方科技大學(xué)，歷任博士后，研究助理教授和研究副教授。主要利用生物化學(xué)、結(jié)構(gòu)生物學(xué)及細(xì)胞生物學(xué)等手段，研究人體和病原體內(nèi)生物大分子的結(jié)構(gòu)與功能。近年來(lái)主要從事分子馬達(dá)蛋白介導(dǎo)的胞內(nèi)物質(zhì)運(yùn)輸?shù)姆肿訖C(jī)制研究。
研究領(lǐng)域：
結(jié)構(gòu)生物學(xué)；細(xì)胞內(nèi)物質(zhì)運(yùn)輸。
工作經(jīng)歷：
2023 - 至今，南方科技大學(xué)，生命科學(xué)學(xué)院，研究副教授；
2019 - 2023，南方科技大學(xué)，生命科學(xué)學(xué)院/前沿與交叉科學(xué)研究院，研究助理教授；
2016 - 2019，南方科技大學(xué)，生物系，博士后。
學(xué)習(xí)經(jīng)歷：
2009 - 2015，中國(guó)科學(xué)院生物物理研究所，生物化學(xué)與分子生物學(xué)，博士；
2005 - 2009，南開(kāi)大學(xué)，生命科學(xué)，學(xué)士。
代表文章：
1. Niu, F.*, Li, L.*, Wang, L., Xiao, J, Xu, S., Liu, Y., Lin, L., Yu, C.#, Wei, Z.#. Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat. Comm. 2024 Jan. (accepted)
2. Jia, X.*; Lin, L.*; Xu, S.; Li, L.; Wei, Z.; Yu, C.#; Niu, F.# Crystal Structure of the SH3 Domain of ASAP1 in Complex with the Proline Rich Motif (PRM) of MICAL1 Reveals a Unique SH3/PRM Interaction Mode. Int. J. Mol. Sci. 2023, 24, 1414. https://doi.org/10.3390/ijms24021414
3. Niu, F.*#, Liu, Y.*, Sun, K.*, Xu, S., Dong, J., Yu, C., Yan, K., Wei, Z#. Autoinhibition and Activation Mechanisms Revealed by the Triangular-shaped Structure of Myosin Va. Sci Adv. 2022 Dec 9;8(49):eadd4187. doi: 10.1126/sciadv.add4187. Epub 2022 Dec 9. PMID: 36490350.
4. Liu Y, Li L, Yu C, Zeng F, Niu F#, Wei Z#. Cargo Recognition Mechanisms of Yeast Myo2 Revealed by AlphaFold2-Powered Protein Complex Prediction. Biomolecules. 2022 Jul 26;12(8):1032. doi: 10.3390/biom12081032. PMID: 35892342; PMCID: PMC9330073.
5. Liang, M.*, Jin, G.*, Xie, X.*, Zhang, W., Li, K., Niu, F., Yu, C., Wei, Z. Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep. 2021 Mar 23;34(12):108901. doi: 10.1016/j.celrep.2021.108901. PMID: 33761347.
6. Niu, F.*, Sun, K.*, Wei, W., Yu, C., Wei, Z. F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis. Sci Adv. 2020 Nov 6;6(45):eabb1307. doi: 10.1126/sciadv.abb1307. PMID: 33158857; PMCID: PMC7673715.
7. Li, J. *, Rodriguez, J. P. *, Niu, F., Pu, M., Wang, J., Hung, L. W., … & Ouyang, S. (2016). Structural basis for DNA recognition by STAT6. Proceedings of the National Academy of Sciences, 113(46), 13015-13020.
8. Burakova, L. P., Natashin, P. V., Malikova, N. P., Niu, F., Pu, M., Vysotski, E. S., & Liu, Z. J. (2016). All Ca 2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin. Journal of Photochemistry and Photobiology B: Biology, 154, 57-66.
9. Jiao, L.*, Ouyang, S.*, Shaw, N., Song, G., Feng, Y., Niu, F., … & Liu, Z. J. (2014). Mechanism of the Rpn13-induced activation of Uch37. Protein & Cell, 1-15.
10. Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., … & Han, W. (2014). Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin. PLoS pathogens, 10(5), e1004109.
11. Niu, F.*, Shaw, N*., Wang, Y. E.*, Jiao, L.*, Ding, W., Li, X., … & Liu, Z. J. (2013). Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation. Proceedings of the National Academy of Sciences, 110(22), 9054-9059.
12. Jiao, L.*, Ouyang, S.*, Liang, M.*, Niu, F.*, Shaw, N., Wu, W., … & Liu, Z. J. (2013). Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. Journal of virology, 87(12), 6829-6839.
13. Niu, F., Ru, H., Ding, W., Ouyang, S., & Liu, Z. J. (2013). Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & cell, 4(9), 687-694.
14. Ouyang, S.*, Song, X.*, Wang, Y.*, Ru, H.*, Shaw, N., Jiang, Y., Niu, F., … & Liu, Z. J. (2012). Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity, 36(6), 1073-1086.
(*co-first author, #corresponding author)