師資
個(gè)人簡(jiǎn)介：
何漣，醫(yī)學(xué)院藥理學(xué)系副教授，博士生導(dǎo)師。2018年于美國(guó)德州農(nóng)工大學(xué)獲得博士學(xué)位，隨后在美國(guó)德州農(nóng)工大學(xué)生物科學(xué)與技術(shù)研究所從事博士后研究。2022年5月加入南方科技大學(xué)醫(yī)學(xué)院。實(shí)驗(yàn)室聚焦合成生物學(xué)前沿領(lǐng)域，利用蛋白工程和光-化學(xué)遺傳學(xué)研究細(xì)胞及組織生理和病理的分子機(jī)制，研發(fā)新一代時(shí)空精準(zhǔn)免疫治療方案與納米抗體藥物，并開(kāi)發(fā)單細(xì)胞水平“光控”基因編輯與藥物篩選平臺(tái)。到目前共發(fā)表四十多篇研究和綜述論文。第一作者或通訊作者相關(guān)成果發(fā)表在Nature Cell biology, Nature Chemical Biology, Nucleic Acids Research, Advanced Science, Nature Communications, elife等國(guó)際期刊。
教育背景：
2004.09 – 2008.06 中山大學(xué)，生命科學(xué)學(xué)院，生物技術(shù), 學(xué)士
2008.09 – 2011.06 中山大學(xué)，生命科學(xué)學(xué)院，分子進(jìn)化，碩士
2012.09 – 2018.05 美國(guó)德州農(nóng)工大學(xué)，醫(yī)學(xué)院，醫(yī)學(xué)科學(xué)，博士
工作經(jīng)歷：
2018.06 – 2022.03 美國(guó)德州農(nóng)工大學(xué)，生物科學(xué)與技術(shù)研究所，博士后
2022.05 – 至今 南方科技大學(xué)，醫(yī)學(xué)院，助理教授
獲獎(jiǎng)情況及榮譽(yù)：
2021年 3rd Prize Winner, 34th Annual Symposium, Society of Chinese Bioscientists in America-TX,
2021年 3rd Prize Winner, Outstanding Poster Awards (Postdoc), Research Symposium, TAMU
2018年 Best Poster Award, 2018 FASEB Research Conference
2017年 Chinese Government Award for Outstanding Self-financed Students Abroad
2017年 Robert and Anabel Bruce Travel Award, TAMU
2017年 Texas A&M IBT Travel awards, TAMU
2016年 Pre-doctoral Research Fellowship, The Welch Foundation
2016年 Outstanding Poster Awards, Gulf Coast Consortia (GCC), Houston
2013年 Outstanding Poster Awards, Texas A&M IBT Research Symposium, TAMU
研究領(lǐng)域：
（1）CRAC鈣離子通道信號(hào)傳導(dǎo)的分子機(jī)制研究及免疫抑制藥物篩選
（2）光遺傳學(xué)介導(dǎo)免疫調(diào)控及時(shí)空精準(zhǔn)免疫治療
（3）新一代光/化學(xué)遺傳合成生物學(xué)工具及設(shè)備的開(kāi)發(fā)與應(yīng)用
（4）新型小分子抗體的活性調(diào)控及抗體藥物研發(fā)
發(fā)表論文：
（#共同第一作者; *共同通訊作者 ）
1. Tan P*, Hong T, Cai X, Li W, Huang Y, He L*, Zhou Y*. Optical control of protein delivery and partitioning in the nucleolus. Nucleic Acids Research 2022, doi: 10.1093/nar/gkac191.
2. Tan P#, He L#, Huang Y, and Zhou Y. Optophysiology: illuminating cell physiology with optogenetics. Physiological Reviews 2022,102(3):1263-1325.
3. Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y, Zhou Y, and Han W. Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Advanced Science 2022,25;e2103940.
4. He L#, Huang Z#, Huang K#, Chen R, Nguyen N, Wang R, Cai X, Huang Z, Han G, Zhou Y and Jing J. Optogenetic control of non-apoptotic cell death. Advanced Science 2021,8(13):2100424.
5. He L#, Tan P#, Zhu L#, Huang K#, Nguyen N, Wang R, Guo L, Li L, Yang Y, Huang Z, Huang Y, Han G, Wang J and Zhou Y. Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology 2021,17(8):915-923.
6. He L*, Tan P, Huang Y*, Zhou Y*. Design of smart antibody mimetics with photosensitive switches.
Advanced Biology 2021,5(5):e2000541.
7. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Huang Y, Wang Y, and Zhou Y. Engineering of a bona fide light-operated calcium channel. Nature Communications 2021,12(1):164.
8. Wang T#, He L#, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y. Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style. Advanced Science 2021,8(3):2002148.
9. Tan P#, He L#, Zhou Y. Engineering supramolecular organizing centers for optogenetic control of innate immune responses. Advanced Biology 2021, 5(5):e2000147.
10. Ma G#, He L#, Liu S#, Xie J, Huang Z, Jing J, Lee YT, Wang R, Luo H, Han W, Huang Y and Zhou Y. Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications 2020,11(1):1039.
11. Lee YT, He L*, and Zhou Y*. Expanding the chemogenetic toolbox by circular permutation. Journal of Molecular Biology 2020, 432(10):3127-3136.
12. Tan P, He L, Xing C, Mao J, Yu X, Zhu M, Diao L, Han L, Zhou Y, You JM, Wang HY, and Wang RF. Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development. Journal of Clinical Investigation 2020,130(10):5349-5369.
13. Liu Z#, Li H#, He L#, Yu X, Tian C, Tan P, Li C, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, and Zhou Y. Discovery of small molecule inhibitors of the HSP90-calcineurin-NFAT pathway against glioblastoma. Cell Chemical Biology 2019,26(3):352-65.
14. Zheng S#, Ma G#, He L#, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko RM, Gill DL, Dong H, Zhou Y, and Wang Y. Identification of molecular determinants that govern distinct STIM2 activation dynamics. PLoS Biology 2018,16(11):e2006898.
15. Nguyen NT#, He L#, Martinze-Moczygemba M, Huang Y and Zhou Y. Rewiring calcium signaling for precise transcriptional reprogramming. ACS Synthetic Biology 2018,16;7(3):814-821.
16. He L#, Jing J#, Zhu L#, Tan P, Ma G, Zhang Q, Nguyen N, Wang J, Zhou Y, Huang Y.Optical control of membrane tethering and interorganellar communication at nanoscales. Chemical Science 2017,8(8): 5275-5281.
17. Tan P, He L, Cui J, Cao X, Qian C, Lin M, Xing C, Zhu Q, Li Y, Yu X, Wang Y, and Wang RF. Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling. Molecular Cell 2017, 68(2):293-307.
18. Tan P, He L, Han G, and Zhou Y. Optogenetic immunomodulation: shedding light on the antitumor immunity. Trends in Biotechnology 2016,35(3):215-226.
19. He L#, Zhang Y#, Ma G#, Tan P#, Li Z, Zang S, Wu X, Jing J, Fang S, Zhou L, Wang Y, Huang Y, Hogan PG, Han G, and Zhou Y. Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015,4:e10024.
20. Jing J#, He L#, Sun A, Quintana A, Ding Y, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y, and Zhou Y. Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nature Cell Biology 2015,17(10):1339-1347. #Featured in News & Views by Nature Cell Biology.
21. Ma G#, Wei M#, He L#, Liu C, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Lee MS, Zhou W, Wang J, Wang Y, and Zhou Y. Inside-out Ca2+ signaling prompted by STIM1 conformational switch. Nature Communications 2015,6: 7826.