師資
個人簡介：
裴國獻從事骨科臨床、教學和科研工作50年，是我國顯微骨科領域具有重要國際影響力的主要領軍人之一和數(shù)字骨科學的開拓者、奠基人。創(chuàng)建了我國嚴重肢體創(chuàng)傷救治理念與新技術體系，解決了極重度肢體創(chuàng)傷保肢的重大技術難題；在國際上最先開展大段骨缺損組織工程再生骨修復研究，被評為骨科權威雜志JBJS（美國版）2010年“骨科學最新研究進展”予以專題介紹；率先在亞洲成功開展異體肢體移植，“代表了當今世界同類手術最高水平，是世界肢體缺失重建領域里一個里程碑”，入選2000年度“中國醫(yī)藥科技十大新聞”；作為重大創(chuàng)新其多項理論和新技術體系被寫入國際教科書和國際專著。
第一完成人獲國家科技進步獎一等獎1項（2020）、二等獎1項（2002）、教育部自然科學一等獎1項、省軍隊一等獎3項和軍隊重大科技成果獎2項；主編專著22部，應Springer邀約主編的Microsurgical Orthopedics，被俄羅斯GEOTAR-Media出版社俄文出版發(fā)行（2021）。第一或通訊作者發(fā)表論文365 篇，其中SCI論文102篇。主持國家863、973、國家自然科學基金重點等項目23項，獲發(fā)明專利17項。
裴國獻任國務院學位委員會學科評議組成員、中華醫(yī)學會顯微外科學分會第七屆主任委員、國際復合組織異體移植學會首任秘書長、《中華創(chuàng)傷骨科雜志》總編輯等職務。被授予國家級有突出貢獻專家、國務院特殊津貼專家、全國首屆中青年醫(yī)學科技之星、全國百千萬人才工程首批人選等國家級榮譽和稱號。
研究領域：
再生骨科研究、智能與數(shù)字骨科
工作經(jīng)歷：
2019.11至今 南方科技大學醫(yī)學院 講席教授
2019.11至2024.1 南方科技大學醫(yī)院 院長
2008.8至2019.10 第四軍醫(yī)大學（現(xiàn)空軍軍醫(yī)大學）西京骨科醫(yī)院、全軍骨科研究所 院長、所長
1997.8至2008.7 第一軍醫(yī)大學（現(xiàn)南方醫(yī)科大學）南方醫(yī)院創(chuàng)傷骨科 主任
1986.6至1994.6 解放軍第153醫(yī)院全軍顯微外科中心 副主任、主任、副院長
1983.5至1986.5 解放軍第89醫(yī)院全軍創(chuàng)傷外科中心 醫(yī)師
1969.12至1983.4 中國人民解放軍第136醫(yī)院 醫(yī)師
獲獎情況及榮譽：
2023 何梁何利基金科學與技術進步獎
2021 第五屆“白求恩式好醫(yī)生”
2020 國家科技進步獎一等獎（第一完成人）
2015 教育部自然科學獎一等獎(第一完成人)
2006 嚴重肢體創(chuàng)傷修復新技術應用研究 廣東省科學技術一等獎 （第一完成人）
2005 熱帶地區(qū)肢體火器傷基礎與救治研究 軍隊科技進步獎一等獎（第一完成人）
2005 下肢毀損性創(chuàng)傷修復新術式應用研究 軍隊醫(yī)療成果獎一等獎 （第一完成人）
2002 國家科技進步獎二等獎(第一完成人)
1996 全國百千萬人才工程首批人選
1994 國家級有突出貢獻中青年科學技術專家
1994 國務院政府特殊津貼專家
近期發(fā)布文章
1. Lei X, Miao S, Wang X, Gao Y, Wu H, Cheng P, Song Y, Bi L, Pei G. Microgroove Cues Guiding Fibrogenesis of Stem Cells via Intracellular Force. ACS Appl Mater Interfaces. 2023 Apr05;15(13):16380-16393.
2. Sun D, Liu J, Su X, Pei G. Fractional differential equation modeling of the HBV infection with time delay and logistic proliferation. Front Public Health. 2022 Nov 11;10:1036901.
3. Mingkui Shen, Lulu Wang, Li Feng, Chuangye Xu, Yi Gao, Sijing Li, Yulan Wu, Guoxian Pei. Cefazolin/BMP-2-Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects. Oxid Med Cell Longev. 2022 Sep 20;2022:8385456.
4. Zhao W, Guo Y, Xu C, Pei G, Basnet S, Pei Y, Su X. Distal Humerus Morphological Analysis of Chinese Individuals: A Statistical Shape Modeling Approach. Orthop Surg. 2022 Oct;14(10):2730-2740.
5. Mingkui Shen, Lulu Wang, Yi Gao, Li Feng, Chuangye Xu, Sijing Li, Xiaohu Wang, Yulan Wu, Yao Guo, Guoxian Pei. 3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects.Mater Today Bio. 2022 Aug 8;16:100382.
6. Sheng Miao, Jinru Zhou, Bin Liu, Xing Lei, Taoran Wang, Xiaotian Hao, Pengzhen Cheng, Hao Wu, Yue Song, Guoxian Pei, Long Bi. A 3D bioprinted nano-laponite hydrogel construct promotes osteogenesis by activating PI3K/AKT signaling pathway. Mater Today Bio. 2022 Jul 1;16:100342.
7. Mingkui Shen, Lulu Wang, Li Feng, Yi Gao, Sijing Li, Yulan Wu, Chuangye Xu, Guoxian Pei. bFGF-Loaded Mesoporous Silica Nanoparticles Promote Bone Regeneration Through the Wnt/β-Catenin Signalling Pathway. International Journal of Nanomedicine. 2022 Jun 7;17:2593-2608.
8. Pengzhen Cheng, Tianqing Cao, Xueyi Zhao, Weiguang Lu, Sheng Miao, Fenru Ning, Dong Wang, Yi Gao,Long Wang, Guoxian Pei, and Liu Yang. Nidogen1-enriched extracellular vesicles accelerate angiogenesis and bone regeneration by targeting Myosin-10 to regulate endothelial cell adhesion. Bioactive Materials. 2022 Jun,12:185-197.
9. Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX. Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro. Stem Cells Int. 2022 Jan 13;2022:4363632.
10. Yijun He, Wenhao Wang, Shaozhang Lin, Yixi Yang, Lizhi Song, Yihan Jing, Lihao Chen, Zaopeng He, Wei Li, Ao Xiong, Kelvin W.K. Yeung , Qi Zhao, Yuan Jiang, Zijie Li, Guoxian Pei, Zhi-Yong Zhang. Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation. Bioact Mater. 2022 May 27;20:164.
11. Zhang Xinxin, Jiang Xiaorui, Jiang Shan, Cai Xiyu, Yu Shengji, Pei Guoxian. Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells. Stem Cell Res Ther. 2021 Jul 7;12(1):382.
12. Liu B, Li J, Lei X, Miao S, Zhang S, Cheng P, Song Y, Wu H, Gao Y, Bi L, Pei G. Cell-loaded injectable gelatin/alginate/LAPONITE? nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model. RSC ADV 2020, 10(43): 25652-25661.
13. Liu B, Li J, Lei X, Cheng P, Song Y, Gao Y, Hu J, Wang C, Zhang S, Li D, Wu H, Sang H, Bi L, Pei G. 3D-bioprinted functional and biomimetic hydrogel scaffolds incorporated with nanosilicates to promote bone healing in rat calvarial defect model. Materials Science and Engineering: C 2020, 112: 110905.
14. Song Y, Wu H, Gao Y, Li J, Lin K, Liu B, Lei X, Cheng P, Zhang S, Wang Y,Sun J, Bi L, Pei G. Zinc Silicate/Nano-Hydroxyapatite/Collagen Scaffolds Promote Angiogenesis and Bone Regeneration via the p38 MAPK Pathway in Activated Monocytes. ACS APPL MATER INTER 2020, 12(14): 16058-16075.
15. Lei X, Wu H, Song Y, Liu B, Zhang S, Li J, Bi L, Pei G. Effects of cyclic fluid stress at different frequencies on behaviors of cells incubated on titanium alloy. BIOCHEM BIOPH RES CO .2020, 522(1): 100-106.
16. Wu H, Song Y, Li J, Lei X, Zhang S, Gao Y, Cheng P, Liu B, Miao S, Bi L, Yang L, Pei G. Blockade of adrenergic β‐receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo. CELL PROLIFERAT 2020, 53(1).
17. Lei X, Liu B, Wu H, Wu X, Wang X, Song Y, Zhang S, Li J, Bi L, Pei G. The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies. CELL ADHES MIGR 2020, 14(1): 12-23.
18. Li D, Cheng P, Jiang H, Cao T, Wang J, Gao Y, Lin Y, Wang C, Zhang S, Li J, Liu B, Song Y, Yang L, Pei G. Vascularization converts the lineage fate of bone mesenchymal stem cells to endothelial cells in tissue-engineered bone grafts by modulating FGF2-RhoA/ROCK signaling. CELL DEATH DIS 2018, 9(10).
19. Cheng P, Li D, Gao Y, Cao T, Jiang H, Wang J, Li J, Zhang S, Song Y, Liu B, Wang C, Yang L, Pei G. Prevascularization promotes endogenous cell-mediated angiogenesis by upregulating the expression of fibrinogen and connective tissue growth factor in tissue-engineered bone grafts. STEM CELL RES THER 2018, 9(1).
20. Jiang H, Cheng P, Li D, Li J, Wang J, Gao Y, Zhang S, Cao T, Wang C, Yang L, Pei G. Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering. J TISSUE ENG REGEN M 2018, 12(4): e2162-e2171.
21. Song Y, Lin K, He S, Wang C, Zhang S, Li D, Wang J, Cao T, Bi L, Pei G. Nano-biphasic calcium phosphate/polyvinyl alcohol composites with enhanced bioactivity for bone repair via low-temperature three-dimensional printing and loading with platelet-rich fibrin. INT J NANOMED 2018, 13: 505-523.
22. Zhang S, Li J, Jiang H, Gao Y, Cheng P, Cao T, Li D, Wang J, Song Y, Liu B, Wu H, Wang C, Yang L, Pei G. Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPK/mTOR Pathway in a Coculture System. STEM CELLS INT 2018, 2018: 1-12.