師資
一、個(gè)人簡(jiǎn)介
南方科技大學(xué)副教授，博士生導(dǎo)師，國自然優(yōu)青。2014年7月本科畢業(yè)于山東大學(xué)生命科學(xué)學(xué)院，2019年7月博士畢業(yè)于清華大學(xué)生命科學(xué)學(xué)院，導(dǎo)師顏寧院士，隨后在西湖大學(xué)生命科學(xué)學(xué)院進(jìn)行博士后研究，導(dǎo)師施一公院士。2021年11月加入南方科技大學(xué)醫(yī)學(xué)院組建研究課題組。近5年的研究主要集中在各類新發(fā)突發(fā)傳染性疾病致病的分子機(jī)制及靶向藥物開發(fā)、人類氨基酸代謝穩(wěn)態(tài)維持的分子機(jī)制兩方面。獨(dú)立前以第一作者、共同第一作者身份發(fā)表多篇頂級(jí)論文，含2篇Nature、3篇Science。獨(dú)立自今兩年多以主要通訊作者身份發(fā)表12篇SCI論文，含1篇Nature Structural & Molecular Biology，2篇Nature Communications，2篇Science Advances，4篇Cell Discovery。谷歌學(xué)術(shù)總被引超8800次，入選2022、2023年度愛思唯爾“中國高被引學(xué)者”，曾獲2021年浙江省自然科學(xué)獎(jiǎng)一等獎(jiǎng)（第二完成人）、2020年度中國六大領(lǐng)域重要醫(yī)學(xué)進(jìn)展、2020年《麻省理工科技評(píng)論》35歲以下的35位創(chuàng)新者之一、2020年全國“博新計(jì)劃十大創(chuàng)新成果”、2019年度中國醫(yī)學(xué)重大進(jìn)展（藥學(xué)部）等多項(xiàng)榮譽(yù)。
二、教育背景
2014/9-2019/7 清華大學(xué) 生物學(xué) （博士學(xué)位）
2010/9-2014/7 山東大學(xué) 生物技術(shù)（學(xué)士學(xué)位）
三、工作經(jīng)歷
2019/7-2021/11 西湖大學(xué)生命科學(xué)學(xué)院 博士后
2021/11-2024/11 南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系 助理教授
2024/12至今 南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系 副教授
四、獲獎(jiǎng)情況及榮譽(yù)
2024年06月 獲得深圳市委教育工作委員會(huì)授予的“兩優(yōu)一先”“優(yōu)秀共產(chǎn)黨員”榮譽(yù)稱號(hào)；
2024年03月 入選2023年度愛思唯爾中國高被引學(xué)者（生物學(xué)者全國共200人入選）
2023年06月 被中共南方科技大學(xué)委員會(huì)授予“南方科技大學(xué)優(yōu)秀共產(chǎn)黨員”稱號(hào)
2023年3月 入選2022年度愛思唯爾中國高被引學(xué)者（生物學(xué)者全國共200人入選）
2021年12月 獲得第一屆全國博士后創(chuàng)新創(chuàng)業(yè)大賽全國創(chuàng)新創(chuàng)業(yè)優(yōu)秀博士后
2021年06月 獲得浙江省自然科學(xué)獎(jiǎng)一等獎(jiǎng) （第二完成人）
2021年06月 被中共浙江省教育廳委員會(huì)授予“全省高校優(yōu)秀共產(chǎn)黨員”稱號(hào)2021年04月 獲得“2020年度中國六大領(lǐng)域重要醫(yī)學(xué)進(jìn)展”榮譽(yù)（新冠肺炎防治）
2020年12月 獲得中國麻省理工學(xué)院科技評(píng)論“2020年度中國35歲以下的35位創(chuàng)新者之一”榮譽(yù)
2020年12月 獲得全國“博新計(jì)劃十大創(chuàng)新成果”
2020年11月 獲得中國博士后科學(xué)基金第68批面上資助二等
2020年06月 入選中國博士后科學(xué)基金會(huì)2020年度博士后創(chuàng)新人才支持計(jì)劃
2020年06月 被中共杭州教育局委員會(huì)授予“2019年度杭州教育系統(tǒng)優(yōu)秀共產(chǎn)黨員”稱號(hào)
2020年01月 獲得“2019年度中國醫(yī)學(xué)重大進(jìn)展”榮譽(yù)（藥學(xué)部）
五、研究領(lǐng)域
各類新發(fā)突發(fā)傳染性疾病致病的關(guān)鍵分子機(jī)制研究及靶向藥物開發(fā)。
六、發(fā)表論文
1. Yingying Guo*?, Renhong Yan?. (2024). A structural snapshot of the multiple working states of the Mpox virus helicase–primase D5. The FEBS Journal. (* indicates co-first authors, ? indicates co-corresponding authors)
2. Haonan Yang*, Huimin Guo*, Aojie Wang*, Liwei Cao*, Qing Fan, Jie Jiang, Miao Wang, Lin Lin, Xiangyang Ge, Haiyan Wang, Runze Zhang, Ming Liao?, Renhong Yan?, Bin Ju? & Zheng Zhang?. (2024). Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants. Nature Communications. (* indicates co-first authors, ? indicates co-corresponding authors)
3. Junyang Xu*, Ziwei Hu*, Lu Dai*, Aditya Yadav*, Yashan Jiang*, Angelika Br?er, Michael G Gardiner, Malcolm McLeod, Renhong Yan?, Stefan Br?er?. (2024). Molecular basis of inhibition of the amino acid transporter B0AT1 (SLC6A19). Nature Communications. (* indicates co-first authors, ? indicates co-corresponding authors)
4. Angelika Broer*, Ziwei Hu*, Jedrzej Kukutowicz*, Aditya Yadav, Ting Zhang, Lu Dai, Renhong Yan?, Stefan Broer?. (2024). Cryo-EM structure of ACE2-SIT1 incomplex with Tiagabine. Journal of Biological Chemistry. (* indicates co-first authors, ? indicates co-corresponding authors )
5. Ziwei Hu*, Renhong Yan?. (2024). Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203. Cell Discovery. (* indicates co-first authors, ? indicates co-corresponding authors )
6. Yaning Li*,Yingying Guo*,Angelika Br?er*,Lu Dai*,Stefan Br?er?, Renhong Yan?. (2024). Cryo-EM structure of the human Asc-1 transporter complex. Nature Communications.(* indicates co-first authors; ? indicates co-corresponding authors)
7. Yaping Shen*, Yaning Li*, Renhong Yan?. (2024). Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus. Structure.(* indicates co-first authors; ? indicates co-corresponding authors)
8. Ximin Chi*, Yiming Chen*, Yaning Li*, Lu Dai*, Yuanyuan Zhang, Yaping Shen, Yun Chen, Tianhao Shi, Haonan Yan, Zilong Wang?, Renhong Yan?. (2024). Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism. Science Advances. (* indicates co-first authors; ? indicates co-corresponding authors)
9. Yingying Guo*?; Songyue Wu*; Wenting Li*; Haonan Yang*; Tianhao Shi; Bin Ju?; Zheng Zhang?; Renhong Yan?. (2024). The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus. Nature Communications. (* indicates co-first authors, ?indicates co-corresponding authors )
10. Yaning Li*；Jing Zhu*；Yingying Guo?；Renhong Yan?. (2024). Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox Virus. Natural Structural & Molecular Biology. (* indicates co-first authors, ?indicates co-corresponding authors )
11. Yaning Li*,Chang Ren*, Yaping Shen*, Yuanyuan Zhang*, Jin Chen, Jiangnan Zheng, Rujun Tian, Liwei Cao?, Renhong Yan?. ( 2023). Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 recepter. Cell Discovery. (* indicates co-first authors, ? indicates co-corresponding authors )
12. Yaning Li*, Yiming Chen*, Yuanyuan Zhang*, Yaping Shen*, Kangtai Xu, Yaqi Liu, ZilongWang?, Renhong Yan?. (2023). Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B0AT1 and ACE2-SIT1. Cell Discovery. (* indicates co-first authors, ?indicates co-corresponding authors )
13. Yaning Li*, Yaping Shen*, Yuanyuan Zhang*, Renhong Yan?. (2023). Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants. Viruses 2023, 15(6). (* indicates co-first authors, ?indicates co-corresponding authors )
14. Renhong Yan*?, Yaning Li*, Yaping Shen*, Ziwei Hu*. (2023). Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant. Science Advances. (* indicates co-first authors, ?indicates co-corresponding authors )
15. Yaping Shen*, Jianhui Wang*, Yaning Li* , Yuanyuan Zhang* , Ruilin Tian? , Renhong Yan?. (2022). Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2. Cell Discovery8. (* indicates co-first authors, ?indicates co-corresponding authors )
16. Yaning Li*, Qing Fan*, Bing Zhou*, Yaping Shen*, Yuanyuan Zhang*, Lin Cheng*, Furong Qi*, Shuo Song*, Yingying Guo*,Renhong Yan?, Bin Ju?, Zheng Zhang?. (2022). Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants. iScience 25(6): 104431. (* indicates co-first authors; ? indicates co-corresponding authors)
17. Yuanyuan Zhang* , Renhong Yan?, Qiang Zhou?. (2022). ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications. Curr Opin Struct Biol 74: 102388. (* indicates co-first authors; ? indicates co-corresponding authors)
18. Yingying Guo*, Yuanyuan Zhang*, Renhong Yan*, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Yi Shi, Qiang Zhou?. (2022). Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nature Communications13. (* indicates co-first authors; ? indicates co-corresponding authors)
19. Yingying Guo*, Yuanyuan Zhang*, Renhong Yan*, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Qiang Zhou?. (2021). Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytopiasmic side. Nature Communications. (* indicates co-first authors; ? indicates co-corresponding authors)
20. RenhongYan*?, Pingping Cao*, Wenqi Song*, Yaning Li*, Tongtong Wang, Hongwu Qian, Chuangye Yan?, Nieng Yan?. (2021). Structural basis for sterol sensing by Scap and Insig. Cell Reports. (* indicates co-first authors; ? indicates co-corresponding authors)
21. Renhong Yan*, Pingping Cao*, Wenqi Song*, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan (2021). A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. (*indicates co-first authors)
22. Renhong Yan*, Yaning Li*,Jennifer Müller*, Yuanyuan Zhang*, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou. (2021). Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discovery. (* indicates co-first authors)
23. Liang Guo*, Wenwen Bi*, Xinling Wang*, Wei Xu*, Renhong Yan*, Yuanyuan Zhang*, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang.(2021). Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. Cell Research31, 98-100. (* indicates co-first authors)
24. Renhong Yan*, Ruoke Wang*, Bin Ju*, Jinfang Yu*, Yuanyuan Zhang*, Nan Liu*, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, YapingShen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang?, Linqi Zhang?, and Qiang Zhou?. (2021) Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Research. (* indicates co-first authors; ? indicates co-corresponding authors)
25. Renhong Yan*?, Yuanyuan Zhang*, Yaning Li*, Fangfei Ye, Yingying Guo, Lu Xia, Xinyue Zhong, Ximin Chi, and Qiang Zhou?. (2021) Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2. Cell Research. (*indicates co-first authors; ? indicates co-corresponding authors)
26. Yuning Chen*, Yanan Zhang*, Renhong Yan*, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang, Yaning Li, Jianxia Ou, Wendi Chu, Zhijuan Liang, Yongmei Wang, Yi-Li Chen, Ganjun Chen, Qi Wang, Qiang Zhou?, Bo Zhang?, and Chunhe Wang?(2021). ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduct Tar 6, 315. (* indicates co-first authors)
27. Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science367, 1444-1448. (First author)
28. Xiangyang Chi*, Renhong Yan*, Jun Zhang*, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang. Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, Lu Xia, Ling Fu, Lihua Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen (2020). A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science369, 650-655. (* indicates co-first authors)
29. Renhong Yan*, Yaning Li*, Yi Shi*, Jiayao Zhou, Jianlin Lei, Jing Huang, Qiang Zhou (2020). Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT. Science Advances6, eaay6379. (* indicates co-first authors)
30. Hongwu Qian*, Xin Zhao*, Renhong Yan*, Xia Yao, Shuai Gao, Xue Sun, Ximing Du,Hongyuan Yang, Catherine C. L. Wong, Nieng Yan. (2020). Structural basis for catalysis and substrate specificity of human ACAT1.Nature 581, 333-338. (* indicates co-first authors)
31. Renhong Yan*, Jiayao Zhou*, Yaning Li*, Jianlin Lei, Qiang Zhou. (2020). Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex. Cell Discovery6. (* indicates co-first authors)
32. Renhong Yan*, Xin Zhao*, Jianlin Lei, Qiang Zhou. (2019). Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature568, 127-130. (* indicates co-first authors)
33. Renhong Yan*, Hongwu Qian*, Ivan Lukmantara, Mingming Gao,Ximing Du, Nieng Yan, Hongyuan Yang. (2018). Human SEIPIN Binds Anionic Phospholipids. Dev Cell47, 248-256 e244. (* indicates co-first authors)