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個人簡介：

曹陽坡, 南方科技大學(xué)醫(yī)學(xué)院副教授，博士生導(dǎo)師，課題組獨立PI。國家級（中組部）高層次青年人才，深圳市鵬城孔雀特聘專家。2020年于北京大學(xué)醫(yī)學(xué)部獲得博士學(xué)位，2020年至2023年在美國哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院從事博士后研究工作。他們實驗室利用一系列高通量、多組學(xué)的方法（包括但不限于AAV-MPRA，AAV-Perturb-seq, HiC, HiChIP, snMultiomics, CASAAV, bioChiP-seq等）, 重點關(guān)注心臟發(fā)育與心肌病的轉(zhuǎn)錄調(diào)控。近5年，曹陽坡博士以第一或通訊作者在Circulation、Circ Res、Nat Cardiovasc Res、PNAS、Dev Cell、Cardiovasc Res、Sci China Life Sci 等領(lǐng)域內(nèi)主流期刊上發(fā)表多篇有影響力的工作。系列研究成果入選美國AHA科學(xué)專刊亮點文章， Nature CVR 亮點文章，心血管領(lǐng)域頂級期刊Circ Res封面文章，亮點文章等。擔(dān)任中國粵港澳大灣區(qū)心臟病協(xié)會等多個協(xié)會常委或委員，國內(nèi)外多本SCI期刊審稿人。

教育背景：

2009年9月-2014年6月  西北農(nóng)林科技大學(xué)，農(nóng)學(xué)，學(xué)士

2014年9月-2020年1月  北京大學(xué)，病理生理學(xué)，博士

工作經(jīng)歷：

2020年1月-2023年3月   哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院，博士后

2023.06-2023.11   南方科技大學(xué)，助理教授

2023.12-至今    南方科技大學(xué)，副教授

獲獎情況及榮譽：

2023獲國家級人才頭銜

2023獲深圳市人才頭銜

2018獲北京大學(xué)學(xué)術(shù)創(chuàng)新獎

研究領(lǐng)域：

1. 心肌細(xì)胞命運調(diào)控的表觀遺傳學(xué)機制

2. 線粒體質(zhì)量控制與心臟病理生理

3. 代謝-表觀遺傳互作與心血管疾病

學(xué)術(shù)任職：

美國心臟協(xié)會(AHA)會員

國際心臟研究會(ISHR)會員

中國粵港澳大灣區(qū)心臟病協(xié)會臨床與基礎(chǔ)研究分會常委

發(fā)表論文：

(#共同一作, *共同通訊)

1. Guo Y#, Cao Y#, Jardin BD#, Mazumdar N, Guo C, Yang L, Lin J, Zhan C, Ma Q, Zhao M, Dong E, Pu WT. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci.2023 Dec;66(12):2939-2942. doi: 10.1007/s11427-023-2385-x. Epub 2023 Aug 11.

2. Sweat ME#, Cao Y#, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity by regulating an atrial enhancer network. Nat Cardiovasc Res. 2023 Oct;2(10):881-898. doi: 10.1038/s44161-023-00334-7. Epub 2023 Oct 12.

3. Feng Xiao#,Xiaoran Zhang#,Sarah U Morton#,Seong Won Kim,Youfei Fan, Joshua M Gorham, Huan Zhang, Paul J Berkson,Neil Mazumdar,Yangpo Cao, Jian Chen,Jacob Hagen,Xujie Liu,Pingzhu Zhou,Felix Richter,Yufeng Shen,Tarsha Ward,Bruce D Gelb,Jonathan G Seidman,Christine E Seidman*,William T Pu*.Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease.Nat Genet. 2024 Feb 20. doi: 10.1038/s41588-024-01669-y. Online ahead of print.

4.  Chaoshan Han#,Junjie Yang#,Tingting Yin#,Junqing An,Aijun Qiao, Yangpo Cao, Yuliang Feng,Haocheng Lu,Ying Wang,Liang Yang, Gangjian Qin*.CD63-snorkel tagging for isolation of exosomes.ScienceDirect.2023 October 26.doi: 10.1016/j.vesic.2023.100031

5.  Zhou P#, VanDusen NJ#, Zhang Y#, Cao Y#, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K*, Pu WT*. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 May 22;58(10):898-914.e7

6.  Cao Y#, Zhang X#, Akerberg BN#, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 Mar 14;147(11):881-896

7. Zhou P#, Zhang Y#, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 Nov 11;131(11):e152-e168

8. Liu R, Xu C, Zhang W, Cao Y, Ye J, Li B, Jia S, Weng L, Liu Y, Liu L, Zheng M. FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia. Cell Death Dis. 2022 Jul 21;13(7):634

9.  Guo Y#, Cao Y#, Jardin BD#, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 Mar 17;119(1):221-235

10.  Xu C, Cao Y, Liu R, Liu L, Zhang W, Fang X, Jia S, Ye J, Liu Y, Weng L, Qiao X, Li B, Zheng M. Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction. J Cell Mol Med. 2022 Feb;26(4):1315-1326

11. Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M. Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2. Life Sci. 2021 Nov 15;285:119918

12. Guo Y#, Cao Y#, Jardin BD#, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008861118

13. Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang C, Liu R, Weng L, Liu Y, Liu L, Zheng M. Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction. Circ Res. 2019 Sep 27;125(8):728-743. doi: 10.1161/CIRCRESAHA.119.315432

14.  Hu H, Jiang M, Cao Y, Zhang Z, Jiang B, Tian F, Feng J, Dou Y, Gorospe M, Zheng M, Zheng L, Yang Z, Wang W. HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. Cardiovasc Res. 2020 Apr 1;116(5):944-955

15.  Cao YP, Zheng M. Mitochondrial dynamics and inter-mitochondrial communication in the heart. Arch Biochem Biophys. 2019 Mar 15;663:214-219

16.  Ye J, Zheng Q, Jia S, Qiao X, Cao Y, Xu C, Weng L, Zhao L, Chen Y, Liu J, Wang T, Cheng H, Zheng M. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein. Hypertension. 2018 Oct;72(4):889-901

17.  Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M. Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts. Cell Death Dis. 2018 May 23;9(6):612

18. Zhang CL, Chen ZJ, Feng H, Zhao Q, Cao YP, Li L, Wang JY, Zhang Y, Wu LL. C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity. Cell Calcium. 2017 Sep;66:90-97

19.  Qiao X, Jia S, Ye J, Fang X, Zhang C, Cao Y, Xu C, Zhao L, Zhu Y, Wang L, Zheng M. PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction. Sci Rep. 2017 Mar 27;7:45379

20.  Jia S, Qiao X, Ye J, Fang X, Xu C, Cao Y, Zheng M. Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction. Cell Death Dis. 2016 Oct 20;7(10):e2432