師資
個(gè)人簡介：
閆凱歌，2011年畢業(yè)于南開大學(xué)物理科學(xué)學(xué)院，取得學(xué)士學(xué)位。同年加入清華大學(xué)高寧教授和雷建林教授課題組攻讀博士，于2016年獲得生物學(xué)博士學(xué)位。之后加入英國劍橋MRC分子生物學(xué)實(shí)驗(yàn)室英國皇家學(xué)會(huì)院士David Barford課題組從事博士后研究。自2010年起，閆博士一直從事結(jié)構(gòu)生物學(xué)領(lǐng)域的研究，多次以第一作者在Nature, Nature Structural & Molecular Biology, Nucleic Acids Research等國際頂級(jí)期刊發(fā)表重要研究成果。2020年10月加入南方科技大學(xué)生物系。
研究領(lǐng)域：
主要利用冷凍電鏡三維重構(gòu)技術(shù)、生物化學(xué)、分子生物學(xué)和細(xì)胞生物學(xué)手段進(jìn)行大分子機(jī)器的結(jié)構(gòu)和功能研究。實(shí)驗(yàn)室的主要研究方向包括：
1. 著絲點(diǎn)(動(dòng)粒)組裝機(jī)制的研究；
2. 核酸蛋白大分子復(fù)合物工作機(jī)制的研究。
工作經(jīng)歷：
2020至今 南方科技大學(xué)生物系 助理教授
2016-2020 英國劍橋MRC分子生物學(xué)實(shí)驗(yàn)室 博士后
學(xué)習(xí)經(jīng)歷：
2011-2016 清華大學(xué) 生命科學(xué)學(xué)院 博士
2007-2011 南開大學(xué) 物理科學(xué)學(xué)院 學(xué)士
代表文章：
1. Yan, K. ?, Yang, J. ?, Zhang, Z. ?, McLaughlin, S.H., Chang, L., Fasci, D., Ehrenhofer-Murray, A.E., Heck, A.J.R. and Barford, D.. (2019) Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome. Nature, 574, 278-282. (? contributed equally to this work).
2. Yan, K. ?,Zhang, Z. ?, Yang, J., McLaughlin, S.H. and Barford, D.. (2018) Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nature structural & molecular biology, 25, 1103-1110.
3. Zhang, D. ?, Yan, K.?, Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Lou, J., Gao, N. and Qin, Y.. (2016) EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome. Nature structural & molecular biology, 23, 125-131.
4. Zhang, D. ?, Yan, K.?, Zhang, Y. ?, Liu, G., Cao, X., Song, G., Xie, Q., Gao, N. and Qin, Y.. (2015) New insights into the enzymatic role of EF-G in ribosome recycling. Nucleic acids research, 43, 10525-10533.
5. Zhang, X. ?, Yan, K.?, Zhang, Y., Li, N., Ma, C., Li, Z., Feng, B., Liu, J., Sun, Y., Xu, Y., Lei, J. and Gao, N.. (2014) Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly. Nucleic acids research, 42, 13430-13439.
6. Wang, W., Li, W., Ge, X., Yan, K., Mandava, C.S., Sanyal, S. and Gao, N.. (2020) Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation. Proc Natl Acad Sci U S A, 117, 15609-15619.
7. Ma, C., Wu, S., Li, N., Chen, Y., Yan, K., Li, Z., Zheng, L., Lei, J., Woolford, J.L.J. and Gao, N.. (2017) Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1. Nature structural & molecular biology, 24, 214-220.
8. Wu, S., Tutuncuoglu, B., Yan, K., Brown, H., Zhang, Y., Tan, D., Gamalinda, M., Yuan, Y., Li, Z., Jakovljevic, J., Ma, C., Lei, J., Dong, M., Woolford, J.L.J. and Gao, N.. (2016) Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature, 534, 133-137.
9. Gu, J., Wu, M., Guo, R., Yan, K., Lei, J., Gao, N. and Yang, M.. (2016) The architecture of the mammalian respirasome. Nature, 537, 639-643.
10. Ma, C., Yan, K., Tan, D., Li, N., Zhang, Y., Yuan, Y., Li, Z., Dong, M., Lei, J. and Gao, N.. (2016) Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation.Protein & cell. 7,187-200.
11. Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N. and Sui, S.F.. (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. eLife, 4.
12. Yang, Z., Guo, Q., Goto, S., Chen, Y., Li, N., Yan, K., Zhang, Y., Muto, A., Deng, H., Himeno, H., Lei, J. and Gao, N.. (2014) Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence. Protein & cell, 5, 394-407.