師資
基本概況:
張斌田,南方科技大學(xué)環(huán)境科學(xué)與工程學(xué)院副教授(研究員、博士生導(dǎo)師、課題組長)。本科畢業(yè)于南開大學(xué),博士畢業(yè)于中科院生態(tài)中心,先后在中科院福建物構(gòu)所及美國亞利桑那州立大學(xué)從事研究工作,入選國家級海外高層次人才及深圳市孔雀特聘崗位。主要研究方向?yàn)榄h(huán)境分析化學(xué),圍繞低濃度環(huán)境污染物的快速檢測、污染物的毒性篩查以及分子毒理學(xué)研究,發(fā)展高靈敏的生物分析技術(shù)、生物傳感器及便攜式檢測設(shè)備等。主持包括國家自然科學(xué)基金在內(nèi)的科研項(xiàng)目多項(xiàng)。在國內(nèi)外學(xué)術(shù)期刊發(fā)表研究論文30多篇,其中以第一及通訊作者身份在PNAS、JACS、ACS Nano、Nano Letters、AC等頂級刊物發(fā)表論文10余篇。獲得授權(quán)國際專利(PCT)、美國及中國專利6項(xiàng),實(shí)現(xiàn)專利技術(shù)轉(zhuǎn)讓2項(xiàng)。曾獲“亞利桑那州立大學(xué)技術(shù)轉(zhuǎn)讓優(yōu)秀獎”、“ACS 特殊貢獻(xiàn)獎”等獎勵。在單分子蛋白電導(dǎo)的基礎(chǔ)理論及應(yīng)用領(lǐng)域做出了一系列原創(chuàng)性成果,被美國科學(xué)促進(jìn)會(AAAS)網(wǎng)站、Science Daily、PHYS.ORG、Physics World等十多家國際主流科技媒體報(bào)道。
工作經(jīng)歷:
2022.12 - 至今 南方科技大學(xué) 副教授(研究員)
2021.09 - 2022.11 南方科技大學(xué) 助理教授(副研究員)
2016.10 - 2021.06 亞利桑那州立大學(xué) 副研究員 (Stuart Lindsay課題組)
2015.01 - 2016.10 中科院福建物構(gòu)所 副研究員(林璋課題組)
2012.07 - 2014.12 中科院福建物構(gòu)所 助理研究員(林璋課題組)
教育背景:
2007 - 2012 中科院生態(tài)環(huán)境研究中心,環(huán)境科學(xué),博士學(xué)位(導(dǎo)師:郭良宏研究員)
2003 - 2007 南開大學(xué),環(huán)境科學(xué),學(xué)士學(xué)位 (導(dǎo)師:朱琳教授)
代表性科研項(xiàng)目:
1. “基于單分子蛋白電導(dǎo)的內(nèi)分泌干擾物與蛋白相互作用研究”,面上項(xiàng)目,國家自然科學(xué)基金委員會,2023.01-2026.12(在研,項(xiàng)目負(fù)責(zé)人)
2. “基于分子印跡技術(shù)的光電化學(xué)傳感器檢測酚類內(nèi)泌干擾物 ”,青年基金項(xiàng)目,國家自然科學(xué)基金委員會,2014.01-2016.12(結(jié)題,項(xiàng)目負(fù)責(zé)人)
3. “基于ZnO納米花的光電化學(xué)傳感器研究”,福建省青年基金項(xiàng)目,福建省科學(xué)技術(shù)廳, 2014.01-2016.12(結(jié)題,項(xiàng)目負(fù)責(zé)人)
4. “面向PTS快速檢測與重度污染土壤治理的實(shí)用化納米材料與技術(shù)研究”,973項(xiàng)目,科技部,2013.01-2017.12 (結(jié)題,參與)
5. “表面包裹和濃度對水溶性II-IV 族熒光量子點(diǎn)生長機(jī)制和尺寸調(diào)控的影響”,面上項(xiàng)目,國家自然科學(xué)基金委員會,2013.01-2016.12。(結(jié)題,參與)
獲獎及榮譽(yù):
亞利桑那州立大學(xué)技術(shù)轉(zhuǎn)讓優(yōu)秀獎、ACS特殊貢獻(xiàn)獎、中科院三好學(xué)生、中科院優(yōu)秀學(xué)生獎學(xué)金、南開大學(xué)優(yōu)秀學(xué)生獎學(xué)金、國家獎學(xué)金、優(yōu)秀本科畢業(yè)論文等。
研究方向:
1. 環(huán)境分析化學(xué)
2. 新型生物傳感器及分析儀器研制
3. 單分子檢測技術(shù)研究
4. 污染物毒性篩查
5. 污染物快速分析檢測技術(shù)開發(fā)
(歡迎具有環(huán)境科學(xué)、化學(xué)、材料等相關(guān)學(xué)科背景的同學(xué)報(bào)考碩士及博士研究生;也歡迎具有相關(guān)背景的博士后加入,一起探索有挑戰(zhàn)的研究課題)
課程教學(xué):
ESE336 - 環(huán)境分析化學(xué)(本科生)
ESE5096 - 環(huán)境生物分析化學(xué)(研究生)
學(xué)術(shù)成果:
發(fā)表論文(#: 同等貢獻(xiàn), *: 通訊作者)
1. Hu, Q., Ren, G., Ye, J., Zhang, B.*, Rensing, C. & Zhou, S*. Hygroelectric-photovoltaic coupling generator using self-assembled bio-nano hybrids. Chemical Engineering Journal 452, 139169, (2023).
2. Tang, L., Yi, L., Jiang, T., Ren, R., Nadappuram, B. P., Zhang, B., Wu, J., Liu, X., Lindsay, S., Edel, J. B. & Ivanov, A. P. Measuring conductance switching in single proteins using quantum tunneling. Science Advances 8, eabm8149, (2022).
3. Hu, Q., Ma, Y., Ren, G., Zhang, B. & Zhou, S. Water evaporation–induced electricity with Geobacter sulfurreducens biofilms. Science Advances 8, eabm8047, (2022).
4. Zhang, B.#, Ryan, E.#, Wang, X., Song, W. & Lindsay, S. Electronic Transport in Molecular Wires of Precisely Controlled Length Built from Modular Proteins. ACS Nano 16, 1671-1680, (2022).
5. Zhang, B.#, Ryan, E.#, Wang, X. & Lindsay, S. Probing Bioelectronic Connections Using Streptavidin Molecules with Modified Valency. J. Am. Chem. Soc. 143, 15139-15144, (2021).
6. Ren, G., Wang, Z., Zhang, B., Liu, X., Ye, J., Hu, Q. & Zhou, S. A facile and sustainable hygroelectric generator using whole-cell Geobacter sulfurreducens. Nano Energy 89, 1-8, (2021).
7. Zhang, B., Song, W., Brown, J., Nemanich, R. & Lindsay, S. Electronic conductance resonance in non-redox-active proteins. J. Am. Chem. Soc. 142, 6432-6438, (2020).
8. Zhang, B. & Lindsay, S. Electronic decay length in a protein molecule. Nano Lett. 19, 4017-4022, (2019).
9. Zhang, B.#, Deng, H.#, Mukherjee, S., Song, W., Wang, X. & Lindsay, S. Engineering an enzyme for direct electrical monitoring of activity. ACS nano 14, 1360-1368, (2019).
10. Zhang, B., Song, W., Pang, P., Lai, H., Chen, Q., Zhang, P. & Lindsay, S. Role of contacts in long-range protein conductance. Proceedings of the National Academy of Sciences 116, 5886-5891, (2019).
11. Xiao, B., Liang, F., Liu, S., Im, J., Li, Y., Liu, J., Zhang, B., Zhou, J., He, J. & Chang, S. Cucurbituril mediated single molecule detection and identification via recognition tunneling. Nanotechnology 29, 365501, (2018).
12. Zhang, B.#, Song, W.#, Pang, P., Zhao, Y., Zhang, P., Csabai, I., Vattay, G. & Lindsay, S. Observation of giant conductance fluctuations in a protein. Nano futures 1, 035002, (2017).
13. Zhang, B., Lu, L., Huang, F. & Lin, Z. [Ru (bpy) 3] 2+-mediated photoelectrochemical detection of bisphenol A on a molecularly imprinted polypyrrole modified SnO2 electrode. Anal. Chim. Acta 887, 59-66, (2015).
14. Wu, Y., Yang, X., Zhang, B. & Guo, L.-H. An electrochemiluminescence biosensor for 8-oxo-7, 8-dihydro-2′-deoxyguanosine quantification and DNA repair enzyme activity analysis using a novel bifunctional probe. Biosens. Bioelectron. 69, 235-240, (2015).
15. Wang, C., Zhang, Y., Guan, M., Cui, L., Ding, K., Zhang, B., Lin, Z., Huang, F. & Zeng, Y. Specific detection of mercury (II) irons using AlGaAs/InGaAs high electron mobility transistors. J. Cryst. Growth 425, 381-384, (2015).
16. Lu, L., Yue, X., Lin, F., Huang, F., Zhang, B.*& Lin, Z.* Template-synthesized ultra-thin molecularly imprinted polymers membrane for the selective preconcentration of dyes. J. Mater. Chem. A 3, 10959-10968, (2015).
17. Zhang, B., Lu, L., Hu, Q., Huang, F. & Lin, Z. ZnO nanoflower-based photoelectrochemical DNAzyme sensor for the detection of Pb2+. Biosens. Bioelectron. 56, 243-249, (2014).
18. Ding, K., Wang, C., Zhang, B., Zhang, Y., Guan, M., Cui, L., Zhang, Y., Zeng, Y., Lin, Z. & Huang, F. Specific detection of alpha-fetoprotein using AlGaAs/GaAs high electron mobility transistors. IEEE Electron Device Lett. 35, 333-335, (2014).
19. Wu, Y., Zhang, B. & Guo, L.-H. Label-free and selective photoelectrochemical detection of chemical DNA methylation damage using DNA repair enzymes. Anal. Chem. 85, 6908-6914, (2013).
20. Ren, X.-M., Guo, L.-H., Gao, Y., Zhang, B.-T. & Wan, B. Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination. Toxicol. Appl. Pharmacol. 268, 256-263, (2013).
21. Li, M.-J., Wu, Y.-P., Zhang, B.-T. & Guo, L.-H. Detection and application of DNA abasic sites. Chin. J. Anal. Chem. 41, 965-972, (2013).
22. Zhang, B., Guo, L.-H. & Greenberg, M. M. Quantification of 8-OxodGuo Lesions in Double-Stranded DNA Using a Photoelectrochemical DNA Sensor. Anal. Chem. 84, 6048-6053, (2012).
23. Zhang, B. & Guo, L.-H. in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. (AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA).
24. Zhang, B. & Guo, L.-H. Highly sensitive and selective photoelectrochemical DNA sensor for the detection of Hg2+ in aqueous solutions. Biosens. Bioelectron. 37, 112-115, (2012).
25. Zhang, B., Du, X., Jia, S., He, J. & Guo, L. Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor. Science China Chemistry 54, 1260, (2011).
代表性專利
1. “Method for electronic detection and quantification of antibodies”, Stuart Lindsay,Bintian Zhang, WO2019217600A1, Nov. 14, 2021 (US/PCT)
2. “Bioelectronic circuits, systems and methods for preparing and using them”, Stuart Lindsay,Bintian Zhang,Hanqing Deng, WO2020160300A3, Sep. 10, 2020 (US/PCT)
3. “Direct electrical readout of nucleic acid sequences”, Stuart Lindsay,Bintian Zhang,Hanqing Deng, WO2020257654A1, Dec. 24, 2020 (US/PCT)
4. “Methods for sequencing biopolymers”, Stuart Lindsay, Eathen Ryan, Bintian Zhang, Xu Wang, US20220389502A1, Jun. 3, 2022 (US)