師資
個(gè)人簡(jiǎn)介：
理學(xué)博士，2013年獲東北師范大學(xué)博士學(xué)位，主要從事腫瘤發(fā)生，發(fā)展和轉(zhuǎn)移的分子機(jī)制研究，涉及生物化學(xué)、分子生物學(xué)，細(xì)胞生物學(xué)多個(gè)學(xué)科領(lǐng)域。目前發(fā)表學(xué)術(shù)論文13篇，包括第一作者論文Cancer Research（2012）、Oncogene（2020）、Oncotarget（2016）、BBRC（2013）等論文。主持國(guó)家自然科學(xué)基金1項(xiàng)，中國(guó)博士后科學(xué)基金1項(xiàng)，廣東省自然科學(xué)基金1項(xiàng)，深圳市科技項(xiàng)目2項(xiàng)；獲得吉林省科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)1項(xiàng)、吉林省自然科學(xué)學(xué)術(shù)成果二等獎(jiǎng)1項(xiàng)、2015年吉林省優(yōu)秀博士學(xué)位論文以及2012年博士生國(guó)家獎(jiǎng)學(xué)金。
教育背景：
2008.09-2013.06年：東北師范大學(xué)，生命科學(xué)學(xué)院，細(xì)胞生物學(xué)專業(yè)，博士
2004.09-2008.06年：廊坊師范學(xué)院，生命科學(xué)學(xué)院，生物科學(xué)專業(yè)，本科
工作經(jīng)歷：
2021.01-現(xiàn)在：南方科技大學(xué)，醫(yī)學(xué)院，研究助理教授
2017.04-2020.12：深圳大學(xué)，醫(yī)學(xué)部，副研究員
2014.10-2017.04：中國(guó)科學(xué)院深圳先進(jìn)技術(shù)研究院，醫(yī)藥所，博士后/助理研究員
2014.05-2014.09：徐州醫(yī)學(xué)院，助理研究員
2013.09-2014.03：美國(guó)國(guó)家癌癥研究中心，博士后
獲獎(jiǎng)情況及榮譽(yù)：
2017年11月，吉林省科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng) 排名第四
2015年10月，吉林省自然科學(xué)學(xué)術(shù)成果二等獎(jiǎng) 排名第四
2015年10月，2015年吉林省優(yōu)秀博士學(xué)位論文
2013年06月，東北師范大學(xué)2013年度博士生科研獎(jiǎng)一等獎(jiǎng)
2013年06月，東北師范大學(xué)優(yōu)秀畢業(yè)研究生
2012-2013學(xué)年，東北師范大學(xué)優(yōu)秀研究生
2012-2013學(xué)年，東北師范大學(xué)研究生優(yōu)秀獎(jiǎng)學(xué)金
2012年12月，教育部博士生國(guó)家獎(jiǎng)學(xué)金
2011-2012學(xué)年，東北師范大學(xué)研究生優(yōu)秀獎(jiǎng)學(xué)金
2009-2010學(xué)年，東北師范大學(xué)學(xué)術(shù)活動(dòng)先進(jìn)個(gè)人
2009-2010學(xué)年，東北師范大學(xué)研究生優(yōu)秀獎(jiǎng)學(xué)金
研究領(lǐng)域：
腫瘤發(fā)生和轉(zhuǎn)移的分子機(jī)制
發(fā)表論文：
(1) Jianchao Zhang, Xinxin Lin, Liufeng Wu, Jia-Jia Huang, Wen-qi Jiang, Thomas Kipps, and Suping Zhang, Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis. Oncogene, 2020, 39(12):2550-2567.
(2) Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li and Hongchang Li, NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 7(38):61036-53.
(3) Jianchao Zhang, Qian Liang, Yang Lei, Min Yao, Lili Li, Xiaoge Gao, Jingxin Feng, Yu Zhang, Hongwen Gao, Dong-Xu Liu, Jun Lu, and Baiqu Huang, SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression. Cancer Research, 2012, 72(17):4597-608.
(4) Jianchao Zhang, Yang Lei, Xiaoge Gao, Qian Liang, Lili Li, Jingxin Feng, Yu Zhang, Baiqu Huang, and Jun Lu, p53 attenuates the oncogenic ras-induced epithelial-mesenchymal transition in human mammary epithelial cells. Biochemical and Biophysical Research Communications, 2013, 434(3):606-13.
(5) Suping Zhang, Han Zhang, Emanuela M. Ghia, Jiajia Huang, Liufeng Wu, Jianchao Zhang, Sharon Lam, Yang Lei, Jinsong He, Bing Cui, George F. Widhopf II, Jian Yu, Richard Schwab, Karen Messer, Wenqi Jiang, Barbara A. Parker, Dennis A. Carson, and Thomas J. Kipps, Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. Proc Natl Acad Sci U S A, 2019, 116(4):1370-1377.
(6) Ximing Shao, Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li and Huashun Li, Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Research, 2016, 26(5):593-612.
(7) Qian Liang, Lili Li, Jianchao Zhang, Yang Lei, Liping Wang, Dong-Xu Liu, Jingxin Feng, Pingfu Hou, Ruosi Yao, Yu Zhang, Baiqu Huang, and Jun Lu, CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Scientific Reports. 2013, 14;3:2932.
(8) Jingxin Feng, Guiying Xu, Jiwei Liu, Na Zhang, Lili Li, Jiafei Ji, Jianchao Zhang, Lian Zhang, Guannan Wang, Xiuli Wang, Jiang Tan, Baiqu Huang, Jun Lu, Yu Zhang, Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer. Breast Cancer Research and Treatment. 2016, 159(3):443-56.
(9) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su, and Hongchang Li, Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. Molecular Cancer Therapeutics, 2018, 17(5):988-1002.
(10) Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li, and Huashun Li, Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Scientific Reports. 2016, 16;6:21019.
(11) Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li, Huashun Li, Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters. 2015, 597:97-103.
(12) Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu and Baiqu Huang, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International Journal of Cancer, 2011, 128:551-61.
(13) Dongmei Su, Xiue Peng, Shan Zhu, Ying Huang, Zhixiong Dong, Yu Zhang, Jianchao Zhang, Qian Liang, Jun Lu, Baiqu Huang, Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells. Biochemical Journal, 2010, 433(2):333-43.
(14) Hanqing Shi, Hui Huang, Xitao Zhang, Jianchao Zhang, Xiutan Luo, Xiue Peng, Baiqu Huang, Jun Lu, c-Myc attenuates the ability of doxorubicin to reduce the colony formation partially through regulating Nbs1 in U2OS cells. Progress in Biochemistry and Biophysics, 2010, 37(8):855-63.